Olimpia 3 – Flamengo 2 (Copa Libertadores, March 28, 2012) Sergio Orteman put Olimpia ahead. Vagner Love equalised from a Ronaldinho assist but Olimpia then took control with goals from Pablo Zeballos and Eduardo Aranda. Dario Botinelli pulled a fine goal back for Flamengo.
Universidad Catolica 2 – Union Espanola 1 (Copa Libertadores, March 28, 2012) Roberto Ovelar put the home side ahead on 8. Gonzalo Villagra equalised with four minutes to go but with two minutes left David Gazzale won the match.
Defensor Sporting 1 – Chivas 0 (Copa Libertadores, March 28, 2012) Nicolas Olivera scored the only goal of the game in the 71st minute.