Two of the bottom three go head-to-head in North Lanarkshire, making this a truly massive game for both.
Ross County start the weekend at the foot of the table, but would draw level on points with their hosts if they are victorious.
The Staggies’ miserable form continued last weekend, beaten 2-0 by Livingston in Dingwall.
That defeat means Malky Mackay’s men have accumulated just a solitary point from their last six outings, this coming in a goalless draw at Pittodrie.
So, can Ross County leap off the foot of the table with a victory?
As for Motherwell, their own winless streak continued on Sunday, beaten 3-2 by Hibs at home.
Stuart McKinstry and Ross Tierney did both half the deficit during the second period, but neither could spark a full-scale comeback.
That defeat means Stevie Hammell’s men are now winless in eight, only victorious in two of their last 16 Premiership matches.
These win came against the sides currently below the Well, both on the road, winning 1-0 at Dundee United and 5-0 in the Highlands when these two clubs last met in early-October.
Here, can the Steelmen claim their first home since since 20 August, thereby plunging Ross County into further peril?