Manchester United head into the game with a slight advantage as they drew 2-2 away from home in the previous leg.
However, Barcelona are still expected to prove a stern test when they travel to Old Trafford on Thursday.
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Predicted Manchester United line-up vs Barcelona
Manchester United team news vs Barcelona
Christian Eriksen and Donny van de Beek are missing with long-term problems.
However, Scott McTominay returned to the bench over the weekend vs Leicester.
Elsewhere, Lisandro Martinez and Marcel Sabitzer are back from suspension.
Both Antony and Anthony Martial remain doubts for Thursday’s tie.
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