Valencia won 4-1 at El Sadar in September but have actually only won three of their last eight meetings with Osasuna. Since victory at Mestalla in 2004, los Rojillos are winless in 14 visits.
Both teams to score is 1/1.
Valencia to win and both teams to score is 4/1.
Hugo Duro is 9/2 to break the deadlock and 13/8 to score anytime.
Can Valencia close the gap on the European places?
Last weekend, los Murciélagos could only draw 1-1 with Rayo Vallecano, despite taking the lead through Carlos Soler at Campo de Fútbol de Vallecas.
Nevertheless, this extends los Che's league run to six matches, winning three of those.
Next Saturday, Valencia will take on Real Betis in the Copa del Rey Final at Estadio de La Cartuja, aiming to regain a trophy they won as recently as 2019.
If they win that, José Bordalás' side would qualify for the Europa League group stages, which is just as well given their league position.
Valencia are currently ninth, four points below the last European spot, should they lose next weekend's cup final.
Osasuna meanwhile are actually just one point and one place below their hosts.
Jagoba Arrasate's side beat Alavés in dramatic circumstances last weekend with Ante Budimir snatching a stoppage time winner at El Sadar.
That 1-0 success means Osasuna have won their last three home games, whilst simultaneously losing their last three on the road.
Nevertheless, having finished tenth and then 11th since promotion, Osasuna are on course for another secure mid-table season.
Will Valencia get the win they need at Mestalla?
Valencia team news
With Jasper Cillessen still out, Giorgi Mamardashvili will continue to deputise in goal, set to start next weekend's cup final too.
At the other end of the field, star striker Maxi Gómez is currently out with a toe injury.
So, Hugo Duro could lead the line, flanked by Gonçalo Guedes and Carlos Soler.
USA international Yunus Musah hobbled off last weekend and the extent of his injury is currently unknown.
Osasuna team news
Jagoba Arrasate will continue to deploy the exciting front three of Ante Budimir, Chimy Ávila and Rubén García.
Behind them Darko Brašanac, Jon Moncayola and Lucas Torró are a very well-balanced midfield trio and are key to Osasuna's success.
La Liga table:
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