Both previous meetings between these two have produced home wins, 1-0 to Chicago and 3-1 to Miami, both last season.
Inter Miami to continue this trend and win this one is 10/11.
Both teams to score is 3/4.
Gonzalo Higuaín has scored 13 goals in 39 MLS appearances so far. He is 10/3 to break the deadlock and 1/1 to add to his tally.
Kacper Przybyłko meanwhile has scored 40 goals since the start of the 2019 season. He is 7/1 to open the scoring and 9/4 to net anytime.
Will Club Internacional de Fútbol Miami, belatedly, become a force in Major League Soccer?
This will be Inter Miami's third season and, to date, they've finished 19th and then 20th in the overall standings, winning just 19 of 57 games.
Thus, significantly better is expected of Phil Neville and his team after he led them to 11th, out of 14, in last year's Eastern Conference.
The Herons have been busy in the off-season, losing Lewis Morgan, Federico Higuaín, Jay Chapman, Nicolás Figal and others.
In have come DeAndre Yedlin, Damion Lowe, Ariel Lassiter, Jean Mota, Robert Taylor, Leonardo Campana on loan and many more.
Gonzalo Higuaín will still be leading the line for Miami but fellow big name Blaise Matuidi isn't expected to feature, although nothing is official yet.
To summarise, this roster is jack-packed full of talent, but whether or not that leads to results on the field remains a large question mark.
It's been all change 1,300 miles north in Chicago too.
The Fire finished way down in 22nd last season, meaning they've only made the play-offs in one of the last nine seasons (2017).
So, Ezra Hendrickson is the new Head Coach in Illinois and he'll be joined by some star signings.
Kacper Przybyłko has com in from Philadelphia Union for $1.15 million GAM while Mexican Jairo Torres will occupy a young DP spot.
But, the headline arrival is two-time UEFA Champions League winner Xherdan Shaqiri who, at 30 years old, still has a lot to give.
Which underperforming team will make a winning start in 2022 at DRV PNK Stadium?
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