Sevilla will be hoping to call on all their experience in the competition and their strong home record at the Ramón Sánchez Pizjuán Stadium this season.
Los Nervionenses are the record holders of the competition having won it 6 times in total and their expe9iemnce could prove key on Thursday.
Meanwhile, they have lost just once in all competitions at home all season and in La Liga they have won all but three of their matches in their own backyard.
Mir is expected to start up front on Thursday with Sevilla blanking in their last match and Martial only just back from injury.
The striker has netted 11 times for Julen Lopetegui's team this season.
Match preview: Sevilla vs West Ham United
Sevilla ended up just edging past Dinamo Zagreb in the last round as they lost 1-0 in the second-leg.
The competition's record-holders produced a 3-1 win at home but made tough work of the tie losing 1-0 in Croatia.
In La Liga, Sevilla remain second in the table, although Real Madrid are starting to move away and their focus could turn to the Europa League.
Julen Lopetegui will be hoping his side make use of the home leg given their impressive record at the Ramón Sánchez Pizjuán Stadium this season.
Sevilla have won all but three of their home matches in La Liga this term and are undefeated there.
West Ham beaten by Liverpool
West Ham slipped to defeat on the weekend as they were beaten by Liverpool on the weekend.
The Reds defeated the Hammers 1-0 at Anfield in another blow to their European hopes.
David Moyes' side now find themselves 6th in the table but Spurs are level on points with them and have two games in hand.
The east London club were not involved in the previous round of the competition as they won their group and avoided the playoff stage.
Sevilla team news
Anthony Martial is back available for Sevilla after recovering from an injury.
However, both Diego Carlos and Thomas Delaney will be missing.
Carlos picked up a knock on the weekend and Delaney is suspnded.
West Ham United team news
West Ham will be without Jarrod Bowen who has suffered a calf injury.
Andriy Yarmolenko, Angelo Ogbonna and Vladimir Coufal are all also out of the match.
Declan Rice returns having missed the trip to Anfield due to illness.
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