It was all one-way traffic when these two met at Letzigrund last Thursday, so will this one go the same way?
PSV Eindhoven scored five times in a 44 minutes spree a week ago; Yorbe Vertessen, Cody Gakpo and Xavi Simons all on target.
Thus, by the time Jonathan Okita got Zürich on the scoreboard, it was scant consolation.
That 5-1 drubbing lifts PSV onto four points after two matches, having been held to a 1-1 draw by Bodø/Glimt last month.
Ruud van Nistelrooy’s team face group-leaders Arsenal home and then away the next two Thursdays, so will be desperate not to drop points here.
This seems very unlikely, given Zürich’s current form.
In this competition, they’re bottom of the group and pointless, having lost 2-1 to Arsenal and then in the Arctic Circle last month.
Meantime, as reigning Swiss champions, they’re rock bottom of that table too, having failed to win any of their ten league matches, losing six of them.
After enjoying their biggest European away win for a decade last Thursday, PSV could bag another bucket load of goals at Philips Stadion too.