Sevilla demonstrated the difference in quality between the two teams in the first-leg.
Julen Lopetegui's team will be desperate to win a seventh Europa League title this season and ensure they get the job done in Zagreb.
However, the hosts are expected to give them a strong game on Thursday.
Mir is Sevilla's leading scorer with nine goals to his name in total.
The striker netted on the weekend in their 1-1 draw at Espanyol.
He also netted in the league game prior and is in good form heading into Thursday's return leg.
Match preview: GNK Dinamo Zagreb vs Sevilla
Sevilla will take a 3-goal lead to Croatia as they aim to win a seventh Europa League title.
Lopetegui's side produced a strong showing in Spain and have a healthy lead.
Goals from Rakatic, Ocampos and Martial ensured Sevilla won the first-leg.
Sevilla have also being going strong domestically as they sit 2nd in La Liga.
Although, Los Nervionenses were held to a fourth draw in their last five on the weekend, drawing with Espanyol.
Zagreb are not to be written off just yet with the Croatians have produced a strong group stage campaign.
Željko Kopić's side finished just behind West Ham and even defeated the Hammers.
GNK Dinamo Zagreb team news
Josip Misic retruns from a one-game suspsion.
The midfielder had collected three yellow cards.
Sevilla FC team news
Joan Jordan remains suspended for the return leg having been sent off in their final group stage game against Red Bull Salzburg.
He joins the long absentee list which includes; Suso, Gonzalo Monteil, Erik Lamela, Jesus Navas, Jesus Corona and Lucas Ocampos.
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