Just 17 days on from an eventful meeting at Selhurst Park, these two clubs go head-to-head again.
That night, Manchester United looked set to leave South London with all three points, thanks to Bruno Fernandes’ emphatic finish on the cusp of half time.
However, right at the end, Michael Olise’s stunning free-kick thwacked off the crossbar and flew beyond a stranded David de Gea.
This last-gasp draw means Palace have lost just two of their last seven meetings with Man United, so can they spring another surprise at Old Trafford?
Four days after dropping points in South London, Erik ten Hag’s team were beaten in the Premier League for the first time since 6 November, conceding in injury time again, this time at Arsenal.
Nevertheless, the Red Devils remain in fourth place, and have made progress in both cup competitions in the last ten days.
A week ago, they reached the FA Cup fifth round by swatting aside Reading 3-1; Casemiro with a brace.
Meantime, they’ve also booked their place in the Carabao Cup Final, swatting aside Nottingham Forest 5-0 on aggregate, with Anthony Martial and Fred on target in Wednesday’s second leg.
They’ll now take on Newcastle at Wembley in 22 days time, but have no less than six fixtures to negotiate before then.
While Man United have been in action four times since the reverse fixture, Crystal Palace have taken to the field only once.
This came a fortnight ago when the Eagles held high-flying Newcastle to a goalless draw at Selhurst.
Overall, Patrick Vieira’s team have won just one of their last seven league matches, but are still in 12th.
Manchester United come into this having won 12 consecutive home games, their best run for 12 years, ultra-confident of extending that streak further.
Manchester United team news
Christian Eriksen was on the wrong end of a horror tackle from Andy Carroll last Saturday, so is set to miss the rest of the season injured.
In response to this, Man United signed Marcel Sabitzer on loan from Bayern Munich on deadline day, with the Austrian set to make his debut here.
Aaron Wan-Bissaka will continue at right-back, due to Diogo Dalot’s injury.
Up front, Anthony Martial featured for the first time since the Manchester derby win in mid-week, so could displace Wout Weghorst from the start.
Predicted XI (4-3-3): de Gea; Wan-Bissaka, Varane, Martínez, Shaw; Casemiro, Fred, Fernandes; Antony, Martial, Rashford.
Crystal Palace team news
Since their last game, Palace have brought in two new midfielders; Albert Sambi Lokonga on loan from Arsenal and Naouirou Ahamada from Stuttgart.
It’ll be interesting to see of Patrick Vieira throws either into his XI for this tough away game.
At centre-back, Chris Richards started their last two matches, and will keep his place with Joachim Andersen still sidelined.
Wilfried Zaha, who made just four appearances for Manchester United, has scored only three times in 15 appearances against them.
Predicted XI (4-3-3): Guiata; Ward, Richards, Guéhi, Mitchell; Doucouré, Schlupp, Eze; Ayew, Édouard, Zaha.