The last three meetings between these two have all ended in draw. Following an FA Cup semi-final victory in July 2020, Chelsea are winless in eight visits to Old Trafford, their longest barren streak since the 1950s.
Both teams to score is 8/13.
Both teams to score and over 2.5 goals is 1/1.
Chelsea to win and over 2.5 goals is 12/5.
Cristiano Ronaldo has only ever scored once in 16 appearances against Chelsea, albeit the goal was a header in a Champions League Final. He is 9/2 to break the deadlock and 13/10 to address this statistical anomaly.
Kai Havertz has scored 13 goals this season, nine of which have come in 2022. He's 6/1 to score first and 7/4 to net anytime.
Are Manchester United’s Champions League aspirations all over now?
On Saturday, the Red Devils were beaten 3-1 in North London by Arsenal on an afternoon where everything went against the visitors.
Cristiano Ronaldo's smart close-range finish halved the defect, mere moments after the Gunners had converted a penalty.
Then, early in the second half, Man United were awarded a spot-kick of their own.
Curiously, Bruno Fernandes was the Portuguese international who stepped up and, after a hop, skip, jump and shimmy, struck the post.
Diogo Dalot then whacked the other upright, only for Arsenal to go up the other end and rubber stamp the 3-1 victory.
Having also been beaten at Man City, Everton and Liverpool, the latter a 4-0 mauling, Man United have now lost four consecutive away league games for the first time in 41 years.
Back then, Dave Sexton's team went on to finish eighth and this current iteration of Manchester United are on course for something similar.
Ralf Rangnick's men, having only won two of their last eight, are sixth, six points below fourth-placed Arsenal.
After this, the Red Devils have just three games left, Brentford (H), Brighton (A) and Palace (A), and, in truth, the season can't end quickly enough.
Chelsea's Premier League campaign too is essentially petering out, but in very contrasting circumstances.
This is because Thomas Tuchel's team are, almost certainly, going to finish third and they still have an FA Cup Final date in the diary.
On Sunday, the Blues were very nervy against West Ham, understandably so given that they'd lost their previous three home matches.
So, when Jorginho gently caressed an 88th minute penalty straight at Łukasz Fabiański, it looked like being another day of frustration.
But, deep into stoppage time, the Blues did snatch all three points with Christian Pulisic coming off the bench to be the hero.
So, despite their recent slump, Chelsea have actually won seven of their last nine league games.
But, as mentioned, all eyes are on their meeting with Liverpool on 14 May, mainly looking to build up some momentum for that one.
Will Chelsea add to Manchester United's misery by winning at Old Trafford for the first time in nine years?
Manchester United team news
Luke Shaw, Fred and Paul Pogba are all still out injured; the French World Cup winner may well have played his last game for the club.
Meanwhile, they're very lucky Bruno Fernandes is available after he, astonishingly, avoided a red card for a horror tackle on Saturday.
Earlier in the game, Fernandes became the first Man United player to miss the target with two penalties in the same season since Teddy Sheringham in 97/98.
Deeper in midfield, with Fred injured, Scott McTominay will partner Nemanja Matić who made 154 appearances for Chelsea, winning five trophies.
The surprise team news at Arsenal was that Harry Maguire was on the bench.
Since joining Manchester United, he's only missed ten of 110 league games and this is only the third time he's been available but not started.
Nevertheless, Victor Lindelöf could continue as Raphaël Varane's partner.
Cristiano Ronaldo scored his 100th Premier League goal at the weekend but none of these have come against Chelsea.
Chelsea team news
Chelsea are short of defensive options with Antonio Rüdiger, Reece James and Ben Chilwell injured, while Andreas Christensen was taken ill during Sunday's warm-up.
After the West Ham win, Tuchel confirmed Rüdiger will leave this summer, something that seemed inevitable, especially given the current sanctions.
First and foremost, they'll still be without him here, so César Azpilicueta, Thiago Silva and Trevor Chalobah could all keep their places at the back.
Ruben Loftus-Cheek, not so long ago, was the forgotten man but will start for the eighth match running.
Without Mateo Kovačić, N'Golo Kanté and Jorginho could continue as the midfield duo.
In attack, after a completely lifeless display against Arsenal, Romelu Lukaku isn't likely to start against his former employers this midweek.
It's pretty clear that Tuchel's first-choice front-three right now is Mason Mount, Timo Werner and Kai Havertz.
Although, it wouldn't be a surprise if Sunday's hero Christian Pulisic or Hakim Ziyech came into the XI.
- 101 Great Goals may earn commission from links on this page. Our content is always original. Note that all of our reviewers are compensated for contributing content to 101 Great Goals. Learn more.