Not only is this a first top-flight East Midlands derby between the two since 1999, it’s also a battle of the Premier League’s bottom two.
So, it’s all on the line in this huge Monday night clash.
Leicester City have end up in the top half of the Premier League in each of the last five seasons, including back-to-back fifth place finishes, a European semi-final and a first FA Cup triumph.
However, the bubble has very much burst with the Foxes propping up the rest, having now lost six on the bounce.
In their last outing, they were hammered 6-2 at the Tottenham Hotspur Stadium, despite the fact it was 2-2 at the interval.
So, Brendan Rodgers’ team have conceded 22 goals already, the most of any top-flight English club at this stage for 57 years.
After this, Leicester face Bournemouth, Palace, Leeds and Wolves, needing wins or Rodgers will be out of a job.
Nottingham Forest meantime are just one place but three points above their neighbours from 25 miles down the road.
The Reds’ form is also alarming, losing four on the bounce, including back-to-back 3-2 home defeats.
Steve Cooper’s side led in both, but were beaten by both Bournemouth and Fulham at home, which is worrying.
Having signed new fewer than 21 first-team players this summer, it was always going to take time for this team to gel.
Nevertheless, having spent so long trying to get back into the Premier League, the last thing Tricky Trees’ fans want to endure is a meek relegation.
Who will claim three priceless points at the King Power?
Leicester City team news
New centre-back Wout Faes made his Premier League debut in the 6-2 drubbing at Spurs; the definition of a baptism of fire.
He could continue to partner Jonny Evans, after he won his 100th Northern Ireland cap on Tuesday.
Jamie Vardy was only on the bench a fortnight ago, but could return up front in place of Patson Daka.
Çağlar Söyüncü and Ricardo Pereira are long-term injury absentees.
Nottingham Forest team news
Given that they almost made two dozen new signings, Nottingham Forest’s XI is very hard to predict.
Scott McKenna withdrew from the Scotland squad last weekend, but should be fit enough to start.
Wily Boly made his Forest debut against Fulham so he, along-with recent arrivals Remo Freuler and Renan Lodi, could all keep their places.
In attack, Jesse Lingard has been the man to miss out of late, with Morgan Gibbs-White, Brennan Johnson and Taiwo Awoniyi getting the nod.
Moussa Niakhaté and Orel Mangala are both sidelined due to injury.