28 miles separate these two South Coast rivals while, in the Premier League table, they’re actually eight places apart.
Southampton slipped into the bottom three last weekend, despite drawing 1-1 with West Ham on Sunday.
Romain Perraud giving the Saints the lead, with the draw ending a sequence of four successive defeats.
Ralph Hasenhüttl’s team haven’t won since beating Chelsea on 30 August, so now only have Leicester and Forest below them.
In stark contrast, pre-season relegation favourites AFC Bournemouth are up in tenth, five points better off than the visitors.
The Cherries remain unbeaten under Gary O’Neil, winning two and drawing four; every other Premier League club has lost a game since that 9-0 drubbing at Anfield.
On Saturday, they led twice at Fulham, Dominic Solanke and Jefferson Lerma on target, but left Craven Cottage with only a point.
Nevertheless, should Bournemouth avoid defeat here, this would represent their longest top-flight unbeaten streak since February 2018.
Will there be a winner at Dean Court?
Bournemouth team news
With Lloyd Kelly out, Adam Smith is likely to continue at left-back, chosen over Jordan Zemura.
If Smith is booked here, he’d miss Monday night’s trip to West Ham due to suspension.
Dominic Solanke’s goal in the second minute on Saturday will see him lead the line, chosen over Kieffer Moore.
Southampton team news
Roméo Lavia and Tino Livramento are out due to long-term injuries.
Armel Bella-Kotchap hobbled off at the weekend so, if he’s not fit, Duje Ćaleta-Car is set to partner Mohamed Salisu.
Ché Adams and Adam Armstrong led the line on Sunday, but Sékou Mara could come in here.
James Ward-Prowse has scored in two of his last three Premier League appearances against Bournemouth.