Manchester United head into the game on the back of a 2-0 win over Leeds United this past weekend.
However, Barcelona are top of La Liga, have a superb defensive record and United have to face them without some big names.
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Predicted Manchester United line-up vs Barcelona
Manchester United team news vs Barcelona
Manchester United manager Erik ten Hag confirmed last week that the trio of Antony, Scott McTominay and Anthony Martial, who missed out vs Leeds, are also likely to miss the trip to the Camp Nou.
Elsewhere, both Marcel Sabitzer and Lisandro Martinez are suspended for the clash after picking up too many yellow cards in the Europa League and Champions League group stages.
Christian Eriksen is also a long-term absentee, meaning United’s midfield options are limited. But in a boost for the Red Devils, Casemiro will return as his suspension is for domestic games only.
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