Fulham head into the game sat 9th in the league and just three points off 7th.
However, their form has not been great in recent weeks and they were bested by Arsenal last time out.
Predicted Fulham line-up vs Manchester United
Fulham team news vs Manchester United
Tom Cairney has been out with an ankle issue but is expected back after the international break.
Neeskens Kebano and Layvin Kurzawa are long-term absentees and currently have no return date set.
Cedric Soares is unable to face his parent club, Arsenal.