These two clubs kick off just one point apart in the La Liga table, so can Villarreal leapfrog their hosts with a victory?
El Submarino Amarillo had ten points on the board after four games but, in their subsequent four outings, they’ve added just two points to their tally.
Last weekend, Unai Emery’s side were beaten 1-0 by Real Sociedad at Anoeta, punished for not converting their chances.
This has seen Villarreal slip down to ninth, quelling any early-season talk of a top four challenge.
Meanwhile, in the Europa Conference League, Emery keeps making wholesale changes but his team keeps on winning.
On Thursday night, Nicolas Jackson’s goal three minutes from time snatched victory against Austria Wien at Franz Horr Stadium.
This means Villarreal are through as group winners, with two games to spare, having won all their European games this season.
So now, with full focus on La Liga, will Villarreal climb up the table?
As mentioned, one of the teams currently above them is Osasuna.
However, Jagoba Arrasate’s team are actually winless in three, beaten 2-1 by Valencia in a truly crazy game last weekend.
Both sides missed a penalty, Chimy Ávila failing to convert for the hosts, before three red cards were brandished.
Unai García and Rubén Peña both sent off for los Rojillos.
Will there be a winner in, what promises to be, an entertaining affair at Estadi Ciutat de València?