Athletic Club are 23-times Copa del Rey winners, reaching two of the last three finals, so will be hoping to get there once again.
In round one, Álex Berenguer and Nico Williams were on target as the Lions swatted aside fourth-tier Alzira.
The Basque giants haven’t lost at this stage of the Copa since 2003, so Ernesto Valverde’s team will fully be expecting to advance here.
Sestao River Club meantime are seeking to reach round three for the first time since the mid-90s.
The hosts find themselves competing in Segunda Federación right now, part of Spain’s fourth-tier.
They beat Racing de Ferrol from the division above in round one; Leandro Martínez the only scorer of the evening.
This time, Athletic Club will surely be far too strong at Estadio Las Llanas.