Will this finally be the year that Villarreal go all the way in the Copa del Rey?
Despite regularly finishing in the top six of La Liga, el Submarino Amarillo have never reached the final of this competition, beaten in the last four by Barcelona in 2015.
In 2021, they did lift a first-ever major trophy, namely the Europa League, and are set to take this competition very seriously.
On Wednesday night, Quique Setién got his much-needed first victory at Villarreal boss, this a 1-0 win over Espanyol.
This saw the Yellow Submarine rise back up to eighth.
Here, Villarreal should ease through.
Santa Amalia meantime beat Universitario in the preliminary round, to set up this glamour tie.
They currently play their football in Primera Extremeña, part of the sixth-tier, with this their first-ever first round clash.
So, anything other than an emphatic Villarreal victory at Estadio Francisco de la Hera would be a major surprise.