Deportivo Alavés were Copa del Rey finalists as recently as 2017, beaten 3-1 by Barcelona at the Vicente Calderón.
Now, after suffering La Liga relegation last season, el Glorioso will be eagerly anticipating this match-up against top-tier opposition.
Luis García Plaza’s team currently find themselves fifth in the Segunda División, despite actually losing their last four matches.
In this competition, los Blanquiazules have so far seen off both Lleida and Mérida, but will certainly need to raise their game here.
Real Valladolid meantime went in the opposite direction last May, promoted back to La Liga at the first attempt.
Right now, Pacheta’s team sit 15th, five points clear of danger, following a 2-0 defeat to Real Madrid on Friday night.
In this competition meantime, Blanquivioletas have comfortably seen off Barbadás and Arenas Club de Getxo, but the difficulty level should increase here.
Will Valladolid’s Primera División quality shine through at Mendizorroza?