Atlético are unbeaten in in six meetings with Celta, while O Celtiña's last La Liga victory over them in Madrid came way back in 2007.
Both teams to score is 1/1.
Atlético Madrid to win and both teams to score is 11/4.
Can Atlético Madrid start to find some form?
Last weekend, los Colchoneros won an away game without conceding for the first time all season, beating Osasuna 3-0 at El Sadar.
João Félix and Ángel Correa on target with Luis Suárez scoring an outrageous, left-footed long-range strike in between.
However, Diego Simeone's side remain fifth having only amassed 13 points from the last 33 available.
This ratio must improve if they're to secure a top four race.
In midweek though, Atlético were in action in this season's Champions League as Manchester United visited the Spanish capital.
Atleti were totally dominant in the first half and led in just the eighth minute when Renan Lodi's cross was headed in by João Félix.
However, they could not sustain the intensity in the second half and the Red Devils snatched a late equaliser.
If Atlético are to reach the quarter-finals, they must win at Old Trafford in the second leg on 15 March.
Before then, will the champions win back-to-back league games for the first time since November?
Celta de Vigo meanwhile are ninth, harbouring outside hopes of sneaking into a European place.
Although, O Celtiña's ambitions were hampered last weekend as they only draw 1-1 with bottom of the table Levante.
Franco Cervi put the hosts in front at Balaídos before the Frogs equalised late on.
Eduardo Coudet's team have only lost two of 14 matches since the start of November but, having drawn half of them, are struggling to make serious progress.
Will they leave the Wanda Metropolitano with a point or even all three?
Atlético Madrid team news
Antoine Griezmann came off the bench for his first appearance since 12 December on Wednesday so is in contention for more minutes here.
João Félix and Ángel Correa led the line against Manchester United but Griezmann and Luis Suárez are alternatives; Matheus Cunha is injured.
Yannick Ferreira Carrasco was suspended for that one so, given his freshness, is likely to start this one.
Šime Vrsaljko will continue at right-back in the absence of Daniel Wass.
Celta Vigo team news
Celta are likely to go bold with both centre-forward, Iago Aspas and Santi Mina, included in the XI.
Néstor Araújo and Joseph Aidoo are like to continue at centre-back, chosen over José Fontán or Jeison Murillo.
La Liga table:
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