Can Porto keep pace with the two clubs currently above them?
Last Sunday, the champions swatted aside Famalicão at Estádio do Dragão, thanks to Galeno’s brace, with Otávio and Mehdi Taremi also on target.
So, Sérgio Conceição’s side have now won four of their last five Primeira Liga games, only slipping up at high-flying Casa Pia in this period.
As a result, the Dragões start the weekend third, one point below Braga and just five adrift league-leaders Benfica.
Thus, Porto will not want to lose ground, as they make the short 30 mile journey north.
Hosts Vitória de Guimarães are always up for this fixture, desperate to end their seven-game losing sequence against their near-neighbours.
Os Conquistadores have qualified for Europe six times in the last decade, and are very much in the hunt for another top six finish.
However, on Monday night, Moreno’s men were beaten 2-1 by Gil Vicente, with striker Anderson opening the scoring and then getting sent off at Estádio Cidade de Barcelos.
This means Vitória are now winless in seven matches in league and cup, but they are still in a healthy league position, beginning the weekend sixth.
Will Porto prove to be too strong at Estádio D. Afonso Henriques?