Huddersfield will be confident of recording back to back wins in their strong push for promotion.
The Terriers have been in great form lately and are undefeated in 13 matches.
Cardiff are also showing improved form and could prove to be a stern test for Carlos Corberán's side.
Holmes netted a huge winning goal at Craven Cottage on the weekend.
The forward now has five league goals to his name this season.
Match preview: Huddersfield Town vs Cardiff City
Huddersfield Town became just the fifth team to defeat Fulham this season.
The Terriers managed to secure a huge three points as they defeated the league leaders.
Danny Ward and Duane Holmes netted their two goals they won 2-1 at Craven Cottage.
The win lifts Corberán's side into 5th place and five points off the automatic promotion spots.
Cardiff City upturned form
Cardiff City have now lost just once in their last five matches and are enjoying a strong run of form.
Over the weekend, Steve Morison's side held Blackpool to a 1-1 draw.
The Bluebirds have now collected an impressive 10 points from their last five matches.
This has seen them move into 19th and 15 points clear of the bottom three.
Huddersfield Town team news
Tino Anjorin is still not ready to make his first appearance for Huddersfield.
He remains sidelined alongside Alex Vallejo, Pipa, Levi Colwill and Rolando Aarons.
Cardiff City team news
Curtis Nelson and Sean Morrison are both set to remain sidelined for Wednesday's clash.
Max Watters is also set miss out having come off against Coventry with a knock.
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