A classic Battle of Britain fixture between the 19-times champions of England and the 55-times champions of Scotland.
Rangers are back in the Champions League proper after 12 years away but, even after reaching last season’s Europa League Final, they’ve really struggled with the step-up in difficulty level.
So far, Giovanni van Bronckhorst’s team have been pumped 4-0 in Amsterdam, before a 3-0 home defeat to Napoli.
In fairness, the Gers played very well in the latter, Allan McGregor actually saved two penalties, but James Sands’ red card proved costly.
So, if the Light Blues are to secure any sort of post-Christmas European football, they need to start getting points on the board.
Liverpool meantime were walloped 4-1 in Naples, but did bounce back by, just about, beating Ajax on Merseyside.
Joël Matip’s 89th minute header snatching the points.
However, generally, things are not going to plan for Jürgen Klopp’s team, who’ve now won just two of seven Premier League matches.
On Saturday, the Reds went 2-0 down at home to Brighton, then led 3-2, but threw it away and only drew.
Meantime, Rangers hammered ten-man Hearts at Tynecastle; Antonio Čolak scoring twice before Alfredo Morelos and Ryan Kent netted.
So, will the visiting Gers supporters be celebrating an historic victory at Anfield?
Liverpool team news
Liverpool are very short of midfielder options; Naby Keïta, Curtis Jones and Alex Oxlade-Chamberlain are all sidelined.
Thiago is fit so will keep his place; Arthur’s only appearance in Liverpool colours, to date, came against Rochdale in the EFL Trophy.
At the back, boyhood Celtic fans Andy Robertson is out, so Kostas Tsimikas will continue to deputise.
In the middle, Joël Matip is likely to partner Virgil van Dijk, even though ibrahima konaté is fit again.
Roberto Firmino’s brace against Brighton could see him keep his place, chosen over Darwin Núñez.
Rangers team news
It’ll be intersting to see who’s in goal for Rangers.
Jon McLaughlin underwhelmed as number one earlier in the season, then sustained and injury and, despite being fit again, Allan McGregor got the nod on Saturday.
At the back, James Sands is suspended, while Filip Helander and John Souttar are sidelined.
So Ben Davies, who spent 18 months at Liverpool but never played, could start against the team he left as recently as August.
John Lundstram, a Liverpool fan, and former Red Ryan Kent will also be key to Rangers’ success.
Antonio Čolak’s two goals at Tynecastle will see him lead the line, chosen over Alfredo Morelos.