Chelsea to win and both teams to score (3/1)
Chelsea are on a strong run of form recently winning five of their last six matches.
The Blues were dominant against Lille in West London as they won 2-0.
Lille are likely to give them a tougher match in France but Thomas Tuchel's men should be too strong for them.
Kai Havertz to score anytime (7/4)
Havertz has taken Lukaku's spot in Chelsea's line-up and is proving to be a crucial member of Tuchel's s side.
The forward has netted five goals in his last four appearances.
He also netted in in the first-leg of their 2-0 win over Lille last month.
Match preview: Lille OSC vs Chelsea betting tips
Lille face a tough task in getting back into the tie as they trail Chelsea 2-0 on aggregate.
The French side will feel aggrieved not to have scored at least once at Stamford Bridge having had 15 attempts.
Jocelyn Gourvennec's side are enjoying a strong run of form in Ligue 1 as they are unbeaten in five matches.
Following a slow start to their domestic campaign, they are now up into 6th in the table.
The defending French champions are now just six points off a European spot.
Chelsea win in uncertain times
Following the shock news involving their owner Roman Abramovic having the club seized from him, Chelsea have managed to block out the noise, winning back to back matches.
The Blues have defeated Norwich and Newcastle as they look set to wrap up a top-four finish.
They now travel to Lille looking to defend their 2-0 lead over the French champions.
Lille OSC team news
Jonathan David is likely to be Lille's biggest threat in the next round.
The striker has 17 goals to his name this season.
Chelsea team news
Chelsea are set to be handed a much-welcomed boost with the return from illness of Cesar Azpilicueta.
Callum Hudson-Odoi, Ben Chilwell and Reece James all remain sidelined.
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