Liverpool vs Brighton, Fulham vs Newcastle, Southampton vs Everton, Crystal Palace vs Chelsea and Bournemouth vs Brentford then all take place at 3 pm, with West Ham vs Wolves the late kick off.
Sunday’s action then sees Manchester City vs Manchester United and Leeds vs Aston Villa with Leicester vs Nottingham Forest rounding out the game week on Monday.
Here are five talking points ahead of the upcoming gameweek.
North London derby
The first North London derby of the campaign is set to be one of the biggest in years.
Arsenal head into the game sitting pretty atop of the Premier League, whilst Spurs are one of two teams yet to lose a game this season.
Given how well both sides are doing, there is a decent chance they will both be in the tittle race at the back end of the campaign, and Saturday’s match could have a major impact on both that and the top-four race.
Erik ten Hag is set to take part in his first-ever Manchester derby this coming Sunday.
It is a major test for the Dutchman, who has begun to transform United after a dismal start to the season.
Manchester City, though, will be by far and away his biggest test so far, with the onus very much on stopping Erling Haaland. Can Lisandro Martinez step up to the task?
Potter vs Palace
Graham Potter will take charge of his first Premier League game as Chelsea manager this weekend.
He faces an old foe in Crystal Palace. Brighton and Palace are bitter rivals, and Potter has never been able to beat them.
Potter drew all three of his matches as Brighton manager at Selhurst Park 1-1, and was also unable to pick up a win at the Amex.
Chelsea, though, have not lost to Crystal Palace since all the way back in 2017.
Rodgers under pressure
Leicester head into gameweek 9 dead bottom of the Premier League table and as the only side yet to pick up a win.
Leicester face Nottingham Forest, another team struggling for form, who are also in the relegation zone.
Should Leicester fail to pick up three points on Monday, that will surely signal an end to Rodgers’ reign at the King Power.
Can Liverpool step up?
After a very slow start to the campaign, Liverpool are now unbeaten in four games.
They saw off Bournemouth, Newcastle and Ajax, whilst being held to a 0-0 draw vs Everton.
If the Reds are to stand any chance of mounting a title challenge this campaign, they must beat Brighton this weekend.