Liverpool head into the game in pretty woeful form domestically.
Their last two Premier League outings saw them lose to Nottingham Forest and Leeds United, meaning they are now eight points off the top-four.
In the Champions League, meanwhile, Liverpool have already secured qualification, but their hopes of obtaining top spot in Group A were slim heading into the final gameweek.
Liverpool kicked off at Anfield three points behind Napoli but with a seven worse goal difference.
The Serie A side also had a perfect record ahead of kick-off, winning all five of their group games whilst scoring 20 and conceding four.
So, a tough test was expected for Jurgen Klopp and co.
Ahead of the game, meanwhile, Trent Alexander-Arnold has made Liverpool history.
The right-back is starting his 50th Champions League game for Liverpool vs Napoli, and as a result, has become the youngest player in the club’s history to reach that milestone.
Andy Robertson will also make his 50th appearance for the club in the CL if he comes off the bench.