Manchester United travel to Spain on February 16 for a Europa League Round of 32 clash.
Both Barcelona and Manchester United are in good form heading into the match, with the former currently sat eight points clear atop of La Liga.
However, La Blaugrana have been handed a blow ahead of what is sure to be a tight affair.
Sergio Busquets will likely miss the game after spraining his ankle ligament during Barca’s 3-0 win over Sevilla on Monday
The club captain was forced off after only four minutes and was duly sent for tests, from which the club have revealed: “Tests carried out this morning have revealed that Sergio Busquets has a lateral collateral ligament sprain in his left ankle. He is out and his recovery will determine his availability.”
Without Busquets, United transfer target Frenkie De Jong is expected to partner Spanish internationals Pedri and Gavi in midfield.
Grimsby Town vs Luton Town betting tips: FA Cup Fourth Round Replay preview, predictions and odds
Burnley vs Ipswich Town betting tips: FA Cup Fourth Round Replay preview, predictions and odds
