Luton head into the match on the back of what has been a very poor start to the season.
They have only played three matches so far this season due to issues with their stadium at the start of the campaign.
And in the three games they have played have seen them lose all three, concede nine and score just two.
Luton predicted line-up vs Fulham
Luton team news vs Fulham
Dan Potts and Jordan Clark are both expected to be sidelined until after the October international break with ankle problems.
Gabriel Osho has a knee injury and is likely back on October 3.
Thomas Lockyer (thigh) and Alfie Doughty (calf) are in contention to feature this weekend.