FC Porto had a solid group-stage campaign, which saw them top their table with six points.
However, things did not go to plan in the first-leg vs Inter Milan last time out.
Otavio was shown a red card in the 78th minute at the San Siro before Romelu Lukaku scored a late winner.
Predicted FC Porto line-up vs Inter Milan
FC Porto team news vs Inter Milan
Otavio will miss the game due to suspension following his red card in the first leg.
Other than that, Porto do not have any real injury issues ahead of Tuesday’s tie.
Despite sustaining a heel injury against Estoril, Canada international Eustaquio should be fit to feature.
