The gameweek kicks off with a huge clash between Chelsea and Liverpool on Saturday afternoon.
We then see old rivals Arsenal and Manchester United face off on Sunday.
The gameweek is rounded out by Fulham and Tottenham facing off on Monday evening.
Here are five talking points ahead of the upcoming gameweek.
Huge Arsenal test
Arsenal are in superb form this season and currently have just one loss to their name in the Premier League.
That loss came against Manchester United last year. It was a tie that somewhat signalled the start of a new era at Old Trafford, with the Red Devils’ form taking a dramatic upswing shortly after that game.
So, if Arsenal do really want to mount a title challenge in the second half of the campaign, they need to pick up three points vs teams like United – especially when they still need to play Manchester City twice in 2022/23.
Manchester United’s title chance
Sticking with Sunday’s main event, Manchester United’s good form has dragged them fairly close to Arsenal.
Their draw with Crystal Palace in midweek was a setback, but if they can do the double over Arsenal, they should be considered title challengers.
However, they will have to do so with Casemiro, who is suspended for picking up too many yellow cards.
Manchester City’s wobble
Compared to the majority of sides, there is nothing wrong with Manchester City’s form.
However, by their own lofty standards, the Sky Blues are experiencing a bit of a rut.
Man City have had some poor luck in defence when it comes to injuries, but even with John Stones and Ruben Dias back fit, Pep Guardiola opted to leave them on the bench vs Tottenham on Thursday.
Given how shaky City have looked at the back in recent weeks, it may be time for Pep to bring back in his trusted centre-back duo.
Last chance for Lampard
Everton sit 19th in the Premier League table with just four wins to their name all season.
Their previous outing saw them bested by a Southampton side also in dismal form.
So, if the Toffees were to lose to West Ham - who are also in the relegation zone - this week, you would assume that would be curtains for Lampard.
Battle of the mid
The weekend’s Premier League action kicks off with Liverpool and Chelsea going head-to-head.
This would normally be a tie that impacts the title race or top-four. However, Liverpool are 9th and Chelsea are 10th heading into gameweek 21.
So, whilst the quality of football is likely to be lower, this game could prove a stepping stone for one of the two sides to climb back into the race for European football.