After a less than impressive start to the season, Sporting CP need to get back on track.
Rúben Amorim’s team won the title in 2021, finishing as runners-up last season, but they begin this weekend down in seventh.
That’s because the Lions have already been hammered by Porto and then suffered defeats to Chaves and Boavista.
In their last league game, goals from Hidemasa Morita, Pedro Gonçalves and Rochinha saw Sporting crush Gil Vicente 3-1 at Estádio José Alvalade.
They then travelled to Marseille on Tuesday night, sitting pretty at the top of their Champions League group with maximum points.
Despite getting stuck in traffic, once the game did get underway, it was all going to plan for Sporting, who led after just 48 seconds through Francisco Trincão curling shot.
However, goalkeeper Antonio Adán then had a complete nightmare, gifting OM two goals and then getting sent off.
In the end, Leões were thankful to leave Stade Vélodrome having only lost 4-1, still in first place in Group D.
Before the return game with Marseille on Wednesday, will Sporting claim three important league points?
Santa Clara meanwhile finished seventh last season and sixth the year before, but kick off in the relegation play-off place.
Os Açoreanos were beaten 1-0 by Rio Ave last weekend, meaning their sole victory remains the 2-1 success over Marítimo on 4 September.
In takes two and a half hours to fly from Lisbon to Azores, so Sporting will be desperate to make sure the trip to Estádio de São Migue is worth while.