Argentina have won their last four meetings with Italy, a shootout victory in the World Cup semi-final of 1990 followed by three successive friendlies. However, la Albiceleste are winless in four competitive matches against European opposition, only winning six of 16 such games this century.
Italy meantime haven't won any of their last five competitive encounters with CONMEBOL members, a run that dates back exactly 20 years on Friday. Gli Azzurri though are unbeaten in five matches at Wembley, winning the European Championships there last July; this'll be Argentina's first visit to the venue since 2000.
Both teams to score is 5/6.
Both teams to score and over 2.5 goals is 8/5.
Argentina to win in 90 minutes is 7/5.
Lionel Messi has scored against 29 different national teams during his illustrious career. He is 15/4 to break the deadlock and 13/10 to add Italy to this list.
European Champions Italy face Copa América winners Argentina at Wembley as the Finalísima returns to the international football calendar.
This competition is back after 29 years, previously known as the Artemio Franchi Cup.
In the past, France have beaten Uruguay 2-0 in Paris before, eight years later, Argentina defeated Denmark on penalties in Mar del Plata.
So now, under a different name, la Albiceleste will look to retain the trophy they lifted almost three decades ago.
This, of course, isn't the most prestigious trophy on offer, but Argentina won't be too picky having endured a long wait for silverware.
Last July, Ángel Di María's deft dink saw his side beat fierce rivals Brazil 1-0 in the Copa América Final at the Maracanã.
This saw Argentina lift silverware for the first time since 1993, losing in no less than seven finals in the intervening years.
Of course, the one they really want is a third World Cup trophy, hoping to add to the triumphs of 1978 and 1986.
Lionel Scaloni's team will kick off their campaign against Saudi Arabia on 22 November, before taking on Mexico and Poland in Group C.
Right now, la Albiceleste are unbeaten in 31 matches, including friendlies, but their World Cup credentials will be put to the test here.
Although, four-times champions of the world Italy will not get the chance to make that five later this year, failing to qualify.... again.
Safe to say, it's been a peculiar few years for Gli Azzurri who, back in March, suffered the most embarrassing defeat of their entire history.
Their World Cup hopes went up in flames, going down 1-0 at home to North Macedonia in a play-off semi-final, the goal coming deep in stoppage time.
So, Italy have now failed to qualify for back-to-back World Cups for the first time ever, also beaten in the 2018 play-offs by Sweden.
In-between however, they've lifted the Henri Delaunay Trophy for the first time in 53 years, hence why they're competing in this match.
Last summer, Roberto Mancini's team won the European Championships, beating England on penalties in the final at this stadium.
That helped Gli Azzurri set a new world-record for a senior men's national team, going 37 successive matches without defeat.
This streak came to an end in October's Nations League semi-finals against Spain, losing 2-1 at San Siro.
So, with no World Cup to look forward to, Italy will be looking to restore some national pride by lifting this trophy.
Will it be the European or South American champions who prevail in London?
Italy team news
This match will be a memorable one for captain Giorgio Chiellini, who'll retire from international football with 117 caps to his name afterwards.
Both he and Leonardo Bonucci missed the play-off defeat to North Macedonia through injury, but are likely to enjoy one last dance together here.
Internazionale's Alessandro Bastoni, a reported Tottenham target, is the air to the throne when it comes to Italian centre-backs.
In goal, Gianluigi Donnarumma will start a 25th consecutive competitive international.
Leonardo Spinazzola could make his national team return having ruptured his Achilles tendon during the Euro 2020 run.
The midfield trio of Jorginho, Marco Verratti and Nicolò Barella was a key reason behind their success last summer.
In attack, now four-time Capocannoniere winner Ciro Immobile as well as Federico Chiesa will both miss this one injured.
Lorenzo Insigne, who's off to Toronto later this summer, could keep his place on the left, but the other two positions are up for grabs.
Andrea Belotti, Federico Bernardeschi and last Wednesday's Europa Conference League Final matchwinner Nicolò Zaniolo are the leading candidates.
Argentina team news
Likewise, with only friendlies to come later this month, Lionel Scaloni's team will be at full strength.
Of course, this'll feature captain Lionel Messi, winning his 161st cap, looking to add to his 81 goals and one trophy for his country.
Julián Álvarez, on loan from Manchester City, scored six times in River Plate's Copa Libertadores victory over Alianza Lima last week.
So, the 22 year old could start in attack, with Copa América hero Ángel Di María or Lautaro Martínez completing the attack.
Allowing all of this attacking talent to shine is a functional midfield trio, although this one won't feature Leandro Paredes who is injured.
So, Giovani Lo Celso and Rodrigo De Paul could be joined by Guido Rodríguez after his impressive season with Real Betis.
Emi Martínez will be back in goal having sat out March's pair of qualifiers suspended.
At the back, Marcos Senesi could make his senior international debut; he was in a bizarre situation, called up by both Finalísima teams last week.
Although, Germán Pezzella, Cristian Romero and Nicolás Otamendi are above him in the pecking order, with the former pair likely to start.
Romero, like his goalkeeper, is available again after a suspension handed out following the World Cup qualifier controversy in Brazil from September.
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