Buffalo Bills @ Houston Texans: Preview, prediction and odds
The Houston Texans host the Buffalo Bills on Thursday Night Football. Read our in-depth preview here
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Preview for Buffalo Bills @ Houston Texans
A pair of playoff hopefuls meet on Thursday night as the Buffalo Bills travel to Houston to face a Texans team that has quietly fought its way back into the AFC picture.
Buffalo arrives off a 44-point burst against the Tampa Bay Buccaneers, a reminder of how dangerous their offense can be when everything clicks.
Houston offers a very different challenge, though. The Texans have been on a stretch of form that has kept them firmly in contention despite the inconsistency on offense.
With the Bills playing on a short week and heading into one of the league’s toughest defensive environments, the tone of this game could shift toward patience rather than fireworks.
Houston’s defense has been among the league’s most effective, ranking near the top in points allowed, yards per play and third-down stops.
That strength sets up a demanding test for Josh Allen. Buffalo have had issues maintaining rhythm away from home, dropping recent road games in Miami and Atlanta, and now faces another physical opponent.
Offensively, Houston may turn to Davis Mills again with C.J. Stroud still in concussion protocol, and while Mills is a clear step down, the game plan is unlikely to hinge on explosive passing.
The Texans have been comfortable winning ugly, leaning on defense and patience, and that might be enough to keep this contest tight into the fourth quarter.
Prediction for Buffalo Bills @ Houston Texans
Houston Texans
Buffalo Bills
Houston’s defense should dictate the style of the night, pushing the game toward longer drives and fewer scoring swings. Buffalo’s talent edge gives them a path to escape with a win, but Houston has enough control on the defensive side to stay within range. Bills by a narrow margin in a low-scoring game.
How to watch Buffalo Bills @ Houston Texans
The Buffalo Bills-Houston Texans matchup takes place on Thursday, November 20, 2025, kicking off at 20:15 ET (17:15 PT/ 01:15 GMT) from NRG Stadium in Houston.
It will be broadcast on Prime Video in the US and is available to watch on Sky Sports NFL in the UK.
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