Southampton head into the game having picked up a rare win last time out.
The Saints saw off fellow relegation strugglers Everton by two goals to one to go level on points with Frank Lampard’s side.
A win this weekend could move them out of the bottom three but Aston Villa are in good form.
Predicted Southampton line-up vs Aston Villa
Southampton team news vs Aston Villa
Tino Livramento suffered a cruciate ligament rupture back in the 2021/22 season and remains out.
Armel Bella-Kotchap had some shoulder issues before the World Cup, but was fit enough for the bench in the Saints’ first outing post-WC. However, he then tweaked his knee last week and missed out vs Everton, so he is a doubt this weekend.
Theo Walcott picked up a calf issue back in December and is yet to return to action.