The Citizens have found themselves in a group alongside Sevilla, Borussia Dortmund and Copenhagen.
It is a group the Sky Blues are expected to win as they once again look to end their long search for a Champions League trophy.
City reached the final in 2021 and then were knocked out in the semis earlier this year by eventual winners, Real Madrid.
Sevilla, meanwhile, are likely to drop down into the Europa League. They have faced Man City twice before, losing 2-1 and 3-1.
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Ahead of the game, when asked fpr his thoughts on Guardiola, Lopetegui had this to say: “I believe that [he is the best in the world], yes. It is hard to say but, from my perspective, in a very complex world, I feel he has been consistent and continued to grow in all his teams.
“It is easier to manage everything after a victory but in defeat I believe the team has shown strength,” he added. “In these circumstances, the team has shown capabilities of overcoming big rivals in moments, with the feeling of wanting to grow in adversity.
“I want to highlight that in the team. If you rip out a lung and a heart (Carlos and Kounde), you have to try to regenerate again and compete.”
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