Manchester United head into the game looking to bounce back from the 7-0 hammering they received at the hands of Liverpool last weekend.
That result means Tottenham and Liverpool can now catch the Red Devils with relative ease in the coming weeks if they do not start picking up wins again.
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Predicted Manchester United line-up vs Southampton
Manchester United team news vs Southampton
Christian Eriksen and Donny van de Beek are missing with long-term problems.
Marcel Sabitzer also picked up a knock this past week and could miss out vs the Saints.
Elsewhere, Anthony Martial’s latest injury looks set to keep him out for some time:
Erik ten Hag said of the Frenchman: “I don’t have an expectation about [his return]; let him do his work. Several times now, he comes back, and he drops back too quickly. When he is available, then we have an extra option, and a good option, so give him time.”
