Manchester United head into the game looking to regain some confidence after they were put to the sword by Liverpool over the weekend.
Despite the 7-0 hammering, though, Manchester United will be boosted by the fact they have already knocked Barcelona out of this competition recently.
Predicted Manchester United line-up vs Real Betis
Manchester United team news vs Real Betis
Christian Eriksen and Donny van de Beek are missing with long-term problems.
Casemiro and Victor Lindelof picked up knocks in Manchester United’s last outing but should be fine to feature on Thursday.
Elsewhere, Anthony Martial’s latest injury looks set to keep him out for some time:
Erik ten Hag said of the Frenchman: “I don’t have an expectation about [his return]; let him do his work. Several times now, he comes back, and he drops back too quickly. When he is available, then we have an extra option, and a good option, so give him time.”
Who has kept the most clean sheets in a single Premier League season?
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