Barcelona registered their fifth successive league win in midweek by seeing off Atletico Madrid at Camp Nou.
Hansi Flick’s side have a 100% record since losing the season’s first Clasico, edging back above Real Madrid and to the top of the table as a result.
Real Betis are also in a good run of form, with six wins and two draws in their last eight in all competitions.
Manuel Pellegrini’s men enjoyed a 2-0 victory at Sevilla in the derby last weekend.