Will this be the season Villarreal, finally, enjoy a lengthy Copa del Rey run?
Despite being European regulars for almost two decades, el Submarino Amarillo have never reached the final of this competition, their sole semi-final appearance coming in 2015.
In round one, Villarreal enjoyed their biggest-ever victory, demolishing Santa Amalia 9-0.
Samu Chukwueze and Gerard Moreno with braces, while Diego Collado, Álex Baena, José Luis Morales, Francis Coquelin and Étienne Capoue all also netted.
Will this tie be equally as routine?
Guijuelo meantime have reached round two for the first time since 2016; they enjoyed their best-ever run that year, hammered 10-1 by Atlético Madrid over two legs.
This year, the Segunda Federación (fourth-tier) club caused a big upset by ousting Deportivo La Coruña in the first round.
Here though, anything other than an easy Villarreal victory at Estadio Municipal de Guijuelo would be a major surprise.