After a mixed week for Porto, can the keep pace in the title race?
Last Friday night, Sérgio Conceição’s side suffered a massive setback, beaten at home by league-leaders Benfica.
This leaves the Dragões six points adrift, therefore meaning they cannot afford to drop more points here.
On the flip side, Porto did qualify for the Champions League knockout stages on Wednesday, hammering Club Brugge 4-0 in Belgium.
Mehdi Taremi scoring twice while Evanilson and Stephen Eustáquio also netted, with Diogo Costa spectacularly saving two penalties.
Here, will Porto claim three points as they make the long journey west to Ponta Delgada?
Santa Clara are likely to be mere cannon fodder, given their lowly position in the table.
Os Açoreanos begin the weekend in the relegation play-off place, despite winning 1-0 at Vizela last Sunday.
Bruno Messi with a late winner at Estádio do Vizela.
Nevertheless, Mário Silva’s team have won just twice this season, and Estádio de São Miguel is likely to witness a comfortable Porto victory.