Both Wales and Belgium will feature at the World Cup in Qatar in two months time, so preparation is key for both.
These two played out an entertaining 1-1 draw in Cardiff during the summer; Youri Tielemans breaking the deadlock, before Brennan Johnson salvaged a late draw.
Overall, Belgium have only won one of seven meetings with Wales in the last decade, but the Dragons have never been victorious on Belgian soil in seven attempts.
Will that change in Brussels?
Aside from that draw, Rob Page’s team lost their other three Nations League matches in June, first in Poland and then twice at the hands of the Netherlands.
Remarkably, in both meetings with Holland, Wales equalised in stoppage time, only to concede a decisive go-ahead goal straight from kick off.
So, the Dragons sit bottom of the section, three points below Poland, the side they host on the final matchday.
Page’s team will be desperate to still be in touch going into that final game, thereby making that a Sunday night relegation showdown in Cardiff.
Belgium meanwhile were hammered 4-1 by the Dutch on matchday one, but responded by battering Poland 6-1 in their next fixture.
Last time out, Michy Batshuayi was the only scorer as the Red Devils won a hard-fort clash in Warsaw.
So, Roberto Martínez’s team remain three points below Holland, needing to ensure that gap doesn’t grow any further before traveling to Amsterdam at the weekend.
Will Belgium make home advantage count, or can Wales spring a surprise at King Baudouin Stadium?