Having lost at home in the Europa League for the first time in a decade, nothing less than three points will do for Manchester United, as they make the long 1,432 mile pilgrimage to Chișinău.
Last Thursday, Group E’s big two met at Old Trafford, with Real Sociedad winning a generally uneventful affair 1-0.
La Real’s winner came from the penalty spot with Lisandro Martínez penalised for handball; it’s universally agreed that this was a baffling call.
Having not been in action last weekend, and with Sunday’s game against Leeds almost certainly off, Erik ten Hag will be looking for a reaction here.
As for the hosts, outwith true football hipsters, few were familiar with FC Sheriff Tiraspol 12 months ago.
That is until they became the first Moldovan club to qualify for the Champions League group stages before beating Real Madrid 2-1 at the Bernabéu.
Since then though, manager Yuriy Vernydub has joined the Ukrainian Army, with numerous key players also departing.
Thus, Sheriff struggled during the summer qualifiers, narrowly beating HŠK Zrinjski Mostar and Maribor, losing to Viktoria Plzeň and then needing a penalty shootout to oust Pyunik.
Having said all of that, Stjepan Tomas’ side were superb on matchday one, demolishing Omonia 3-0 in Nicosia.
Rasheed Akanbi opening the scoring after less than 100 seconds, before Iyayi Atiemwen and Mouhamed Diop secured the victory.
Given that Sheriff have won 20 of the last 22 Divizia Națională titles, the successfulness of their season is determined in Europe.
Unfortunately for them, due to Transnistria’s close ties with Russia, this game will not take place in Tiraspol.
39 miles west at Zimbru Stadium, it’ll still be a big occasion, so can the Moldovan champions famously defeat Manchester United?