This European campaign has been an unparalleled disaster for Olympiacos meaning, for just the second time in 16 years, they’ll bow out in the group stages.
On matchday one, Evann Guessand’s stoppage time header saw Nantes beat the Greek champions 2-1 at Stade de la Beaujoire.
Olympiacos actually started this campaign with three successive defeats, subsequently stabilising with back-to-back draws.
Youssef El-Arabi broke the deadlock in Freiburg last week but, as it finished 1-1, Míchel’s men are guaranteed to finish bottom.
Nantes meanwhile will compete in a knockout stage in February, but in which competition?
Last Thursday, la Maison Jaune kept alive their hopes of a top two finish, courtesy of another last-gasp home victory.
Ignatius Ganago fired home, in the 95th minute no less, to snatch victory against Qarabağ in northern France.
So, for Antoine Kombouaré's team to take second, they must win here and hope the Azerbaijani champions fail to beat Freiburg in Bakı.
Given that the Bundesliga side have nothing to play for, favours from them may be in short supply.
Will Nantes do all they can at Georgios Karaiskakis Stadium?