Having won on the road in Chișinău, Nice are firmly in pole position to reach the quarter-finals.
Last Thursday, the only goal of the night came in first half stoppage time when Ayoub Amraoui’s cross-come-shot looped over Maksym Koval’s head and into the far corner.
So, back in the French Riviera, Nice are likely to cruise through.
Since taking over as caretaker manager in January, Didier Digard remains unbeaten, with Sunday’s 2-2 draw at Nantes meaning he’s yielded 22 points from ten Ligue 1 games.
This has lifted les Aiglons up to seventh, knocking on the door of the European spots.
Of course, Nice could still qualify for next year’s Europa League by winning this competition.
France’s only remaining representatives on the continent are seeking to reach a quarter-final for the first time since 1960, beaten by Real Madrid in the European Cup back then.
As for FC Sheriff Tiraspol, this’ll be their 34th European match since the start of last season, but is likely to be the end of the road for them.
Although, last month, Roberto Bordin’s team did dump out Partizan Belgrade, winning 3-1 in Serbia having lost the first leg 1-0 at home.
Thus Sheriff, who’ve won 20 of the last 22 Divizia Națională titles, will be hoping for some déjà vu.
Anything other than a comforable home win at Allianz Riviera would be a surprise.
Nice team news
Experienced Brazilian international centre-back Dante cannot play, serving a one-match suspension following a yellow card in Moldova.
Other familiar faces such as Kasper Schmeichel and Ross Barkley could start, while Aaron Ramsey is working his way back to fitness, but Arsenal loanee Nicolas Pépé injured.
Up front, Terem Moffi scored on Sunday, but top-scorer Gaëtan Laborde could return.
FC Sheriff Tiraspol team news
Left-wing-back Patrick Kpozo was booked in the first leg, meaning he’ll be suspended.
Mouhamed Diop was the hero in Serbia last month, scoring twice, having also netted in a 3-0 victory over Omonia in Nicosia during the group phase.