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New England Patriots vs San Francisco 49ers – Preview, predictions, picks, offers and odds

Find out all the best odds, picks, and predictions in an NFL Week 4 match preview between San Francisco 49ers and New England Patriots, with in-depth analysis and the latest stats.

Written by Mike Ifftner
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New England Patriots vs San Francisco 49ers – Preview, predictions, picks, offers and odds

The New England Patriots (1-2) take to the road to face the San Francisco 49ers (1-2) on Sunday at the Levi’s Stadium for a Week 4 matchup. The San Francisco 49ers enter this matchup after a tough loss in their previous game. Nonetheless, they are banking on their home-field advantage to stage a comeback against the New England Patriots in this encounter.

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Match Preview

San Francisco 49ers and New England Patriots odds

Odds for New England Patriots vs San Francisco 49ers is Provided by Bet365. For a full list of odds for the match visit Bet365.com

  • Moneyline (ML): New England Patriots (+375) | San Francisco 49ers (-500)
  • Against the spread (ATS): New England Patriots +9.5 (-110) | San Francisco 49ers -9.5 (-110)
  • Over/Under (O/U): 41.0 (-110) | (-110)

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21+ Please Gamble Responsibly. Gambling Problem? Call or text 1-800-GAMBLER

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