Following last weekend’s promising start, will Fulham be able to build on that here?
The Cottagers, who most predicted would go straight back down again, were also widely expected to be swatted aside by Liverpool at Craven Cottage.
By the end, having led twice, both times through Aleksandar Mitrović, Fulham were actually really unlucky not to beat the Reds, settling for a 2-2 draw.
The Whites have changed division in each of the last five season but this time, under Marco Silva, there are signs that this year could be different.
Goalkeeper Bernd Leno and centre-back Issa Diop, who arrived from West Ham on Wednesday, could make their debuts for the club in this one.
While Fulham are full of optimism, the same cannot be said of Wolverhampton Wanderers.
Despite leading early through Daniel Podence, Wolves were beaten 2-1 at Leeds on the opening day; Rayan Aït-Nouri’s unfortunate own goal proving the difference.
Bruno Lage’s team actually finished tenth last season, but many feared they will be in a relegation battle this time round.
What might improve the mood this week is the arrival of another Portuguese player, namely Gonçalo Guedes from Valencia for €40 million.
Given that Wolves have only scored 73 goals in their last 76 Premier League games, Guedes adds much-needed attacking threat.
Will either claim their first three points of the season at Molineux?