Premier League giants Chelsea and Manchester United saw key members of their respective squads pick up injuries whilst on international duty on Friday.
First came a blow for the former, during Belgium's Nations League meeting with the Netherlands.
The Red Devils endured a miserable night all round, ultimately succumbing to a 4-1 drubbing at the hands of a resurgent Dutch outfit under the watch of Louis van Gaal.
And adding further to the woes of Roberto Martinez's troops was an injury suffered by Romelu Lukaku.
Inside the half-hour mark in Brussels, hitman Lukaku went to ground clutching his right ankle, giving rise to fears of a potential sprain, and incoming spell on the sidelines.
Red Devils concern
Lukaku, though, was far from the only high-profile performer to have been forced into a premature departure across Friday's Nations League fixture list.
Joining the Belgian was fellow striker Kylian Mbappe, who sparked concern both in Didier Deschamps' France setup and back at PSG, owing to what appeared to be a knee issue.
Les Bleus' meeting with Denmark, which saw the Nations League holders slip to an eventual 2-1 defeat, was then soured ever further upon Raphael Varane pulling up just beyond the hour mark.
The Manchester United star was seen clutching at his hamstring, an area which caused Varane persistent problems across the recently-completed campaign.
The hope, of course, will therefore be that his latest setback does not prove to be a serious one.
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