Liverpool pair Philippe Coutinho and Roberto Firmino are set to return to Melwood from international duty next Thursday.
The Reds face rivals Manchester United on Saturday lunchtime in the league.
This means that with the duo playing two games and travelling back from South America, their preparation for the game will be very limited.
This evening, Brazil travel to Bolivia for their penultimate World Cup qualifier.
The five-time world champions have already booked their place at next year’s World Cup in Russia.
Brazil then wrap up their qualification campaign on 11 October against Chile.
This means that Coutinho and Firmino will have very limited time to recuperate and go again on Saturday lunchtime.
Subsequently, this means that the pair may struggle to be 100 percent ready for the 12.30pm kick-off.
Jurgen Klopp is keen for his two Brazilian’s not to feature too heavily given Selecao’s qualification status.
The pair are set to private jet back to England following the conclusion of their game against Chile, which takes place in the early hours of Wednesday morning (UK time).
Liverpool v Manchester United
This is a key fixture for Liverpool, given both the magnitude of the derby and the Reds’ position in the league.
Liverpool are currently undergoing a turbulent patch being held to a frustrating 1-1 draw at Newcastle last Sunday.
Jurgen Klopp’s side find themseleves placed 8th in the league; seven points off of Manchester United.
The German manager and his defence have been heavily criticised over the course of the season, but even more so since last Sunday’s outing.
Liverpool’s defence must now contain a red-hot Manchester United side, who have so far taken the rest of the league by storm.
The likes of Romelu Lukaku, Marcus Rashford and Anthony Martial have proven to be the driving force behind Jose Mourinho’s sides brilliant start.
Liverpool have shown their quality this season, especially against Arsenal at Anfield back in August, and they must reproduce this if they hope to stand a chance coming up against the Red Devils.