The Argentine defender is a long-term target of the San Siro club and it is thought that a deal is nearing completion.
According to reports in his native homeland, all that is left for Milan to do is to stump up the money.
That should not be a problem with the Italian’s set to complete a takeover shortly in which would add some money to their summer transfer fund.
The deal would certainly be a statement of intent as the Italian Giants look to approach next season with big ambitions.
Football italia: Milan have reportedly agreed a €25m deal to sign Villarreal defender and long-term target Mateo Musacchio.
— Il milanisti capo (@ilmilanisticapo) February 24, 2017
One in, one out
Even with a signing set to come in, another is set to leave the San Siro in the next few weeks.
Midfielder Keisuke Honda is set to make a move to the MLS with the club willing to terminate his contract.
The Japanese international has fell down the pecking order and is currently not within the clubs plans going forward.