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Colorado Rapids are unbeaten in five meetings with San Jose Earthquakes, including a 5-0 victory in Denver and a 1-0 win when they visited Northern California last September.
Both teams to score is 8/13.
Colorado to win and both teams to score is 15/4.
Jeremy Ebobisse is 9/2 to break the deadlock and 17/10 to score anytime.
Match preview
Can 2021's best of the west Colorado Rapids climb above the play-off line?
Last weekend, Robin Fraser's side beat Portland Timbers 2-0 at Dick's Sporting Goods Park, ending a run of five games without a victory.
Diego Rubio opened the scoring with a beautiful free-kick, before later getting sent off, with Mark-Anthony Kaye's stoppage time strike sealing the win.
As mentioned, before this, the Rapids hadn't won since recording back-to-back victories over Atalanta and SKC in early-March.
Now, Colorado are looking to claim their first road victory of 2022 at the sixth attempt in all competitions.
San Jose Earthquakes could be the perfect hosts given their own underwhelming start.
The Goonies claimed their first victory of the season a fortnight ago, beating Seattle Sounders 4-3 in an all-time MLS classic in California.
However, last weekend, the Quakes came crashing back down to earth as they were hammered 3-0 in the Bronx by New York City FC.
Alex Covelo remains in interim charge after Matías Almeyda's 103-game tenure was ended on 18 April.
Having only won once so far, San Jose remain second bottom of the Western Conference, just two points above Vancouver.
Will Colorado leave PayPal Park with all three points?
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