These two have met six times in MLS, producing four home wins and one draw. The only away victory came in their very first encounter with Orlando 2-0 winners in Oregon in 2015.
Over 2.5 goals is 17/20.
Portland to win and over 2.5 goals is 15/8.
It's ninth in the west vs fifth in the east with Orlando City the side looking to continue their bright start to the campaign in the cross-conference affair.
Last weekend, in another away game on the other side of the country, the Lions enjoyed a surprise 1-0 victory over LA Galaxy.
Facundo Torres's goal with just nine minutes on the clock proved to be the difference at Dignity Health Sports Park.
That is a second win of the season for Óscar Pareja's team so, despite suffering a surprise home loss to FC Cincinnati, things are looking good for Orlando.
Portland Timbers meanwhile started with back-to-back draws, against New England and LAFC, before a victory over Austin.
However, Giovanni Savarese's side then encountered their first bump in the road, getting hammered 4-1 by FC Dallas in Frisco.
That is just the sixth time since September 2018 Portland have conceded 4+ in any match.
Back at Providence Park, will the Timbers Army see a reaction from last season's MLS Cup finalists?
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